IFNA1 and COVID-19: Herein, we only studied the role of auto-Abs against type I IFN, but Zhang et al. [4] showed that 3.5% of critical COVID-19 patients carry significant inborn errors of type I IFN immunity related to loss of function variants, pointing out that a part of critical COVID-19 patients have an impaired IFN response unrelated to auto-Abs.