IFNA2 and COVID-19: Circulating IgG auto-antibodies (auto-Abs) neutralizing IFN-α2 and/or IFN-ω (10 ng/mL) were found in 10% of critical COVID-19 cases in an international cohort, as compared with 0% of mildly/asymptomatic cases and 0.3% of uninfected individuals [5].