On the other hand, COX-2 inhibition by 20 mg/kg/day celecoxib (CXB-20 plus TST), reversed the imbalance between proliferative and apoptotic signals by inducing a higher ratio of pro-apoptotic Bax per anti-apoptotic Bcl-2 compared with TST-induced BPH (Fig. 7c). This evidence concerns the gene BAX and benign prostatic hyperplasia.