Therefore, the upregulation of Cd74 may suggest that the occurrence and development of congenital cataracts caused by Crim1 mutations is related to the immune system, and pathway analysis also shows that Cd74 is affiliated with the immune system process, antigen processing and presentation, MHC class II antigen processing and presentation and MHC class I antigen processing and presentation. Here, CRIM1 is linked to early-onset non-syndromic cataract.