On the transcriptional level, sebaceous glands of acne patients exhibit decreased nuclear expression of the transcription factors FoxO1 and FoxO3a [11–13] and increased activity of mechanistic target of rapamycin complex 1 (mTORC1) [13–15], a key regulator of sebocyte proliferation, lipogenesis, autophagy end endocrine responses in acne pathogenesis [16–18]. Here, FOXO3 is linked to acne.