In contrast, Western diet with high glycaemic load and milk/dairy consumption increases insulin/IGF-1 signalling promoting AKT/MDM2-mediated proteasomal degradation of p53 [50, 114, 116], whereas forced upregulation of p53-FoxO1 signalling may contribute to the tumour suppressing effect of isotretinoin in neuroblastoma [117] and retinoid chemoprevention of non-melanoma skin cancer [118]. The gene discussed is MDM2; the disease is neoplasm.