Furthermore, FoxO1 promotes the expression of GATA6, a critical transcription factor maintaining appropriate keratinocyte proliferation and differentiation of the infundibulum of the human sebaceous follicle [108], which is deficiently expressed in sebaceous follicles of acne patients linking p53-FoxO1-GATA6 deficiency to comedogenesis. This evidence concerns the gene GATA6 and acne.