FOXO1 and acne: Increased expression of CRABP2 in isotretinoin-treated sebaceous glands of patients with acne has been observed after weeks of oral isotretinoin exposure [46], whereas short-term (6 h, 24 h) isotretinoin exposure of immortalized p53-inactivated SZ95 sebocytes did neither exhibit increased CRABP2 nor upregulated p53 or FoxO1 expression [102].