Interestingly, though EPHX4 has hardly been studied in GIAC, the immunohistochemical (IHC) data from the HPA database revealed that its staining showed moderate to strong cytoplasmic immunoreactivity in CRC and GAD, and weak immunoreactivity in normal colon/rectum and stomach tissues (Supplementary Figures 13, 14). This evidence concerns the gene EPHX4 and colorectal carcinoma.