The cross-sectional analysis indicated that chronological age, maximal oxygen consumption (VO2max), body fat, and blood pressures (diastolic blood pressure and systolic blood pressure) were not associated with the log2-transformed p16INK4a and p21Cip1 levels in peripheral blood mononuclear cell (PBMCs) in sedentary adults with obesity (p > 0.05) (Figure 1A–1C, Tables 2, 3; Supplementary Figure 1). This evidence concerns the gene CDKN1A and obesity due to melanocortin 4 receptor deficiency.