Regarding the circRNAs that were reduced in ALS muscle, hsa_circ_0056856, hsa_circ_0117010, and hsa_circ_0006633 showed a similar decrease in motor neurons; interestingly, the mRNA counterparts of hsa_circ_0056856 and hsa_circ_0141401 (ITGB3 and ALPK2 mRNAs, respectively) were modestly but significantly elevated in the ALS motor neurons, in contrast to what was observed in skeletal muscle (Figure 4C). The gene discussed is ALPK2; the disease is amyotrophic lateral sclerosis.