For the upregulated group, 7 out of 8 circRNAs, hsa_circ_0000119, hsa_circ_0000567, hsa_circ_0007778, hsa_circ_0000099, hsa_circ_0005171, hsa_circ_0000231, and hsa_circ_0001451, were altered without significant changes in the linear counterpart transcripts (MAN1A2, SETD3, SLC25A16, AMY2B, TMEM38B, ARHGAP12, and FBXW7 mRNAs, respectively) suggesting that these circRNAs may have a role in ALS, independent of the associated mRNAs; only hsa_circ_0007099 and its counterpart (ABHD2 mRNA) showed joint increases in abundance (Figure 2A). Here, SETD3 is linked to amyotrophic lateral sclerosis.