Among those circRNAs upregulated in ALS skeletal muscle, C9-ALS motor neurons showed similar increases in hsa_circ_0000119, hsa_circ_0000567, hsa_circ_0007778, hsa_circ_0000099, and hsa_circ_0005171 relative to control motor neurons, while the mRNA counterparts for these circRNAs were not altered; the greatest fold change was seen for hsa_circ_0000119 and hsa_circ_0000099 (Figure 4B). This evidence concerns the gene C9 and amyotrophic lateral sclerosis.