ALK and cancer: We next tested CircFusion on RNA-seq data of cancer cells expressing f-circRNAs and linear fusion transcripts that were previously identified by PCR-based techniques and experimentally validated: 8 APL samples harboring the PML::RARα fusion (3 NB4 cell line and 5 patient samples) [18], and 9 samples of lung adenocarcinoma H3122 cell line with the EML4::ALK fusion [32].