As TIMP-2 has been reported to be a major regulator of matrisome biology [34], gaining an understanding on how different degrees of alterations in TIMP-2 expression in ovarian cancer impacts on different MMPs and their levels in cancer cells and how it may affect cancer cell chemosensitivity, migration/invasion and tumorigenic growth potentially poses a major advancement not only in understanding of TIMP-2 mediated ovarian tumour biology but may also lay the foundation of TIMP-2-based targeted therapy. The gene discussed is TIMP2; the disease is cancer.