KRT14 and ovarian carcinoma: Not only did the gRNA1 cell line in a spheroid-mode showed a significantly greater proliferation than gRNA2, control and parental cell lines, it also expressed significantly higher levels of the basal epithelial invasive marker, KRT14 (Fig. 9C), which has previously been found to be a determinant of invasive potential of leader cells in ovarian cancer [32], indicating that spheroids derived from gRNA1 cell line to be more invasive than spheroids arising from gRNA2, CRISPR control, and parental cell lines.