Our previous study had shown that knock down of TIMP-2 expression by siRNA in Fallopian-tube derived non-malignant (FT282) and ovarian cancer cell lines (OVCAR4 and JOSH2) showed significant upregulation of MMP-14 expression with downregulation of MMP-2 expression (both protein and mRNA) and activation [24]. The gene discussed is MMP14; the disease is ovarian carcinoma.