Our previous work showed that TIMP-2 and TIMP-3 proteins are highly expressed in ovarian carcinomas compared to normal ovarian tissues and benign tumours; TIMP-1 and TIMP-2 proteins are excessively secreted in ascites of ovarian cancer patients; and the mRNA expression of TIMP-2 is significantly lower in ascites-derived tumour cells isolated from chemotherapy treated recurrent patients compared to chemo naive patients [16]. This evidence concerns the gene TIMP3 and ovarian carcinoma.