Consistently, the expression of NUCB2 mRNA in the synovium of patients with RA in GSE77298 (P < 0.01; Fig. 1A), GSE55235 (P < 0.05; Fig. 1B), and GSE1919 (P < 0.01; Fig. 1C) was higher than that in the synovium of normal controls according to the NCBI GEO database. This evidence concerns the gene NUCB2 and rheumatoid arthritis.