PDE4D and neurodegenerative disease: The majority of csDMPs were in CD8+ T cells (n = 48), a handful of which mapped to genes shown to be differentially expressed in animal models of neurodegenerative diseases (e.g. Dynactin Subunit 5[36], Isopentenyl-Diphosphate Delta Isomerase 1 [37], SLIT-ROBO Rho GTPase Activating Protein 1 [38] and Phosphodiesterase 4D [39]).