The expression of SPP1 was absolutely up-regulated in bladder cancer (BLCA), brain and CNS cancer, breast cancer (BRCA), cervical cancer (CESC), esophageal cancer (ESCA), gastric cancer (STAD), head and neck cancer (HNSC), liver cancer (LIHC), lung cancer (LUAD and LUSC), lymphoma, melanoma, ovarian cancer (OV), pancreatic cancer (PAAD) and prostate cancer (PRAD) than in corresponding normal tissues. This evidence concerns the gene SPP1 and central nervous system cancer.