In ovarian cancer, we observed that SPP1 was significantly negatively associated with tumor purity (r = -0.411, p = 4.1e-21) but positively correlated with the levels of infiltrating CD8 + cells (r = 0.143, p = 1.65e-03), CD4 + cells (r = 0.208, p = 4.18e-06), macrophages (r = 0.268, p = 2.28e-09), neutrophils (r = 0.473, p = 4.28–28) and dendritic cells (r = 0.355, p = 1.05e-15), among which, the correlation with neutrophils and dendritic cells having the most prominent relevancy. Here, SPP1 is linked to neoplasm.