The expression of SPP1 was absolutely up-regulated in bladder cancer (BLCA), brain and CNS cancer, breast cancer (BRCA), cervical cancer (CESC), esophageal cancer (ESCA), gastric cancer (STAD), head and neck cancer (HNSC), liver cancer (LIHC), lung cancer (LUAD and LUSC), lymphoma, melanoma, ovarian cancer (OV), pancreatic cancer (PAAD) and prostate cancer (PRAD) than in corresponding normal tissues. The gene discussed is SPP1; the disease is head and neck cancer.