Since tumor tissues have a mixture of tumor and nontumor, especially tumor-infiltrating lymphocytes, and previous studies showed that tumor survival could be predicted by tumor purity and tumor-infiltrating lymphocytes (TILs) [31–34], we further investigated the relationship between SPP1 expression and tumor purity and TIL abundance via TIMER database and TISIDB database. This evidence concerns the gene SPP1 and neoplasm.