In order to study the role and mechanism of immunity in osteoarthritis, we analyzed the relationship between 9 key m6A regulators and immune cell infiltration, among which RBM15B is the m6A regulator most related to immune cell infiltration (Fig. 6C), Suggest that RBM15B is an immune-related regulator in osteoarthritisNext, the case samples of the OA group were then classified into RBM15B low and high expression groups to study the differential expression of a variety of immune cells. The gene discussed is RBM15B; the disease is osteoarthritis.