CD274 and neoplasm: The extra-TLS-zone parameters, including the densities of eICs and PD-L1 expression, were significantly affected by tumor location, histological differentiation, and pStage in the HDL- or LDL-normal group, and differing from the TLS parameter trend, peaks of most extra-TLS-zone parameters occurred at the middle stage of tumor progression rather than the early stage (Fig. 6 A and B).