Similarly, cucurbitacin IIb isolated from Ibervillea sonorae was tested as an antitumoural treatment option for NSCLC in the A549 cell line, reducing cell growth and inducing apoptosis at low concentrations and in a dose-dependent manner, while also inhibiting STAT3 expression and suppressing the activity of EGFR and/or of its downstream proteins [80]. Here, EGFR is linked to non-small cell lung carcinoma.