It had been reported that KAT8 (K-lysine acetyltransferase 8), BMP2, BMP3 (Bone morphogenetic protein), and EP300 were significantly downregulated in breast cancer, as they have a major role in controlling tumor progression through histone acetylation, metastasis suppression and inhibition of EMT, respectively [39–41]. The gene discussed is EP300; the disease is neoplasm.