Furthermore, androstano-arylpyrimidines induced ERS precipitating to decreased multidrug resistance 1 (MDR1)-mediated doxorubicin efflux [37], and lupeol decreased the expression of ABCG2 and activated ERS to induce Oxaliplatin-resistant CRC cell death [38]. This evidence concerns the gene ABCB1 and colorectal carcinoma.