TOP2A and hepatocellular carcinoma: Moreover, it is a vital biomarker for cancers as TOP2A overexpression is associated with several cancers, such as hepatocellular carcinoma (HCC), malignant peripheral nerve sheath tumours, hepatoblastomas, oesophageal cancer, breast cancer, gastroesophageal carcinoma, colorectal carcinoma, pancreatic cancer, and prostate cancer (Heestand et al. 2017; Hooks et al. 2018; Kolberg et al. 2015; Pei et al. 2018).