Among several candidate proteins, heat shock protein 90 regulates the nucleocytoplasmic translocation of HMGB1 (Kim et al. 2021) and mitochondrial heat shock protein 75 (or glucose-regulated protein 75) is involved in HMGB1-induced asthmatic airway inflammation (Lv et al. 2018). This evidence concerns the gene HMGB1 and inflammatory response.