In line with the here observed association of SNORD105B with ER negative tumors, TNBC, and poorer outcome, its upregulation has been detected in colon adenocarcinoma (CoAC) and its oncogenic role in promoting tumor growth and invasiveness possibly by interacting with ALDOA indirectly affecting c-MYC expression was described in gastric cancer49,53. Here, ALDOA is linked to colon adenocarcinoma.