HLA-A and neoplasm: We also analyzed the relationship between HLA-A mRNA expression in primary tumors and paired metastases relative to immune signatures in the RAP dataset of 12 primary tumor–metastasis pairs and identified the same relationship of low HLA-A mRNA and low/lower immune cell gene expression features, which again was the most frequent in basal-like/TNBC (Extended Data Fig. 7a–d).