EPS15L1 and depressive symptom measurement: Of the 16 CpGs they identified as differentially methylated by maternal depression status across six gestational time points, only one CpG in the EPS15L1 gene was also differentially methylated our study by mean maternal EPDS score across gestation (FDR < 0.05), and although the effect was in the same direction, the effect size (Δβ =  + 0.003 with each unit increase in mean EPDS) was well below our biological |Δβ| threshold of > 0.03, and therefore may not be a biologically meaningful change in DNAme.