Thisinflux inhibition disrupts the symbiosis between aerobic (MCT1-expressing)and anaerobic (MCT4-expressing) cells in the tumor microenvironmentby glucose deprivation, first in hypoxic cells, and eventually, normoxiccells, leading to apoptosis, finally increasing the susceptibilityof the tumor cells to first- and second-line antineoplastic agents.17 Here, SLC16A4 is linked to neoplasm.