Since cofilin is needed for invadopodia initiation, stabilization, and maturation [85, 86], and silencing cofilin expression was found to interfere with long-lived invadopodia in metastatic carcinoma cells [64, 87], we determined if androgen treatment of TNBC cells silenced for cofilin affect invadopodia formation and matrix degradation activity. The gene discussed is CFL1; the disease is metastatic carcinoma.