When groups were compared, no significant differences were noted in CSF orexin levels between the EDS+ (278.7, IQR = [235.3–329.2] pg/mL) and EDS- (260.4 [203.6–309.7] pg/mL) groups, and the RBD+ (263.0 [227.8–306.3] pg/mL) and RBD- (271.1 [217.0–336.3] pg/mL) groups. The gene discussed is HCRT; the disease is Ehlers-Danlos syndrome.