Five biologically relevant loci were discovered on individual hernia analyses to confer shared susceptibility to multiple hernia phenotypes including 1q41 (ZC3H11B), 2p16.1 (EFEMP1), 6p22.1 (MHC region), 7q33 (CALD1) and 11p13 (WT1). The gene discussed is EFEMP1; the disease is Hernia.