To our knowledge, this study also represents the first GWAS of hiatus hernia in which we identified eight susceptibility loci of which four loci (2p16.1 (EFEMP1), 6p22.2 (BTN2A1), 7q33 (CALD1), 11p13 (WT1) are known to correlate with abdominal hernia. This evidence concerns the gene WT1 and Hiatus hernia.