Five biologically relevant loci were discovered on individual hernia analyses to confer shared susceptibility to multiple hernia phenotypes including 1q41 (ZC3H11B), 2p16.1 (EFEMP1), 6p22.1 (MHC region), 7q33 (CALD1) and 11p13 (WT1). This evidence concerns the gene CALD1 and Hernia.