TGFB2 encodes the protein Transforming Growth Factor β2 (TGF β2) which is observed to be upregulated in Marfan syndrome, Loeys-Dietz syndrome, and cutis laxa, which are associated with aneurysmal changes with histological features including smooth muscle cell apoptosis [41]. Here, TGFB2 is linked to Loeys-Dietz syndrome.