EFEMP1 and Hernia: To our knowledge, this study also represents the first GWAS of hiatus hernia in which we identified eight susceptibility loci of which four loci (2p16.1 (EFEMP1), 6p22.2 (BTN2A1), 7q33 (CALD1), 11p13 (WT1) are known to correlate with abdominal hernia.