ENPP2 and Hepatic fibrosis: In addition, as biomarkers of liver fibrosis, Type IV collagen (p = 0.753) and FIB-4 index (p = 0.333) did not significantly differ, while Autotaxin (p = 0.006) and APRI (p = 0.003) significantly decreased 48 weeks after pemafibrate administration (Fig. 3).