Altogether, previous studies and our current findings warrant further investigations into the role of NPY in PCa biology and its potential implications for the disease diagnosis, stratification and therapy (Yi et al. 2018; Maschauer et al. 2019; Chastel et al. 2020; Worm et al. 2020; Hoppenz et al. 2020; Ding et al. 2021). This evidence concerns the gene NPY and posterior cortical atrophy.