Considering that autophagy and ubiquitination are two common mechanisms in protein degradation,12 we estimated the protein expression of CLK3 after adding the autophagic inhibitor 3‐MA (2.5 mM) or the ubiquitin proteasome inhibitor MG132 (5 μM) to MFAP2 silenced CRC cells. This evidence concerns the gene MFAP2 and colorectal carcinoma.