Necroptosis was closely related to various pathways, especially interferon gamma response, interferon alpha response, IL6 JAK‐STAT3 signalling, complement, allograft rejection, inflammatory response, TNF‐α signalling via NFkb, apoptosis, IL2 STAT5 signalling, KRAS Signalling Up and p53 pathway (Figure 8); a positive correlation was observed in almost all cancer types. The gene discussed is TP53; the disease is cancer.