Previous studies also showed that FA intervention can induce classic pathological changes of AD, including Aβ deposition, Tau protein hyperphosphorylation and memory impairment in vitro and in vivo (He et al., 2016; Li and He, 2016; Jing and He, 2017; Zhai et al., 2018). The gene discussed is MAPT; the disease is memory impairment.