MAPT and tauopathy: Oral GSPE supplementation is also effective in significantly modulating Tau-mediated pathogenic phenotypes, including Tau hyperphosphorylation, misfolding into fibrillar polymers and subsequently aggregation into AD-type NFT in various tauopathy mouse models (Ho et al., 2009; Wang et al., 2010; Ksiezak-Reding et al., 2012; Santa-Maria et al., 2012).