Six genes (GATA1 (P‐value = 2.52 × 10−2), SELP (P‐value = 1.86 × 10−2), MPL (P‐value = 2.72 × 10−2), F13A1 (P‐value = 1.62 × 10−2), SPARC (P‐value = 2.97 × 10−2) and TLN1 (P‐value = 6.13 × 10−3)) were significantly downregulated in anaphylaxis patients compared with healthy controls (Figure 3). This evidence concerns the gene SPARC and anaphylaxis.