It was also demonstrated that higher BNP/NT-proBNP (B-type natriuretic peptide (BNP) or N-terminal proBNP (NT-proBNP) plasma levels were associated with severe disease (Zinellu et al., 2021b) and mortality (Pranata et al., 2020; Zinellu et al., 2021b) in COVID-19 patients. This evidence concerns the gene NPPB and COVID-19.