Based on the large body of evidence presented in this article, the specific biomarkers, including inflammatory and immunological parameters (CRP, PCT, IL6), hematological (lymphocyte and neutrophil counts, NLR, D-dimer, ferritin, RDW), cardiac (troponin, CK-MB, myoglobin), liver (AST, ALT, total bilirubin, albumin) and lung injury (KL-6), can be used as prognostic biomarkers that can aid the risk stratification and the prediction of serious clinical consequences, including mortality, in COVID19 patients. The gene discussed is CRP; the disease is COVID-19.