Many of these seemed to belong (non-exclusively) to four particular groups: Regulators of synapse stability/organization (Sparc, Sparcl1, C1qb, Cst3, Cpe, Aif1, Mov10); proteins with roles in fatty acid/lipid metabolism (Fads2, Pla2g7, Apoe, App, Cyp51a1, Ormdl3, Mid1ip1, Mov10); proteins related to cell bioenergetics (Hk2, Slc25a13, and Ndufs7, the latter having increased following PSI exposure); and proteins that are implicated in Alzheimer’s disease (AD) pathology or colocalize with Aβ (App, Apoe, A2m, C1qb, Sparc, Cst3, Itm2c). The gene discussed is SPARC; the disease is early-onset autosomal dominant Alzheimer disease.