BRCA1 and prostate cancer: Khan et al. (2021) described the emerging role of natural products in cancer treatment. Among them, soy isoflavones, were reported to target BRCA histones for repair. Through their in vivo experiments, Fan et al. (2006) found that genistein along with indoole-3-carbinol targeted both BRCA1 and BRCA2 genes in breast and prostate cancer cells.