ICD-related DAMPs, including surface-exposed calreticulin (CRT), secreted ATP and high mobility group protein B1 (HMGB1) can be recognized by pattern recognition receptors (PRRs) that are expressed by immune cells, resulting the activation of tumor suppressing immune response [recruitment of antigen presenting cells (APCs) and T cells, etc.] (Galluzzi et al., 2020b). This evidence concerns the gene CALR and neoplasm.