IL1B and COVID-19: Considering that progression to severe COVID-19 is attributed primarily to the hyperinflammatory state where the level of pro-inflammatory markers (i.e., CRP, ferritin and serum cytokines such as IL-1B, IL-8 and sTNFR) is elevated, it is likely that the favorable effect of cannabinoids in mitigating adverse outcomes is mediated through dampening the immunomodulatory response.