Throughout the immune cycle, several steps in cluster 2 involved releasing and presenting cancer cell antigens, extensive recruitment of immune cells, such as CD8 T cells, macrophages, B cells, natural killer (NK) cells, and killing of tumor cells, was more active in cluster 2 than cluster 1, so cluster 2 might be an inflammatory immunophenotype (Figure 1C). The gene discussed is CD8A; the disease is cancer.