Previous studies on non-small cell lung carcinoma demonstrated that circulating miRNA expression signature was associated with the existence of tumor-specific mutation status, such as the EGFR gene mutation (31, 32) It can be hence presumed that genetic alteration in PBMAH would affect tissue miRNA expression and systemic response due to adrenal hyperplasia formation and induce unique circulating miRNA profiles. This evidence concerns the gene EGFR and congenital adrenal hyperplasia.