Though we have not characterized any NGS derived concordant tumor-centric variants, high-risk variants identified in HCC patients using GATK and SnpEff tools correspond to transcripts of EGFR, CTNNA1, PTPA, AKT1, MTOR, ARAF, RAF1, HRAS, CREB3, SREBF1, ACY1, STAT3, etc. These genes correspond to well-known cancer pathways. Here, CREB3 is linked to hepatocellular carcinoma.