Both VEGF and FGF upregulate an activator of glycolysis 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) in tumor ECs (TECs), while FGF also activates a glycolytic enzyme HK2 (15, 16). The gene discussed is VEGFA; the disease is neoplasm.