MSH2 and breast cancer: Besides PLAB2 (correlated to breast cancer), BRCA1 (connected to ovarian and breast cancer), and p16/CDKN2A (associated with risk of melanoma and familial atypical multiple mole melanoma), DNA mismatch repair genes like hMSH2, hMLH1, hPMS1, hPMS2, and hMSH6/GTBP (Lynch syndrome), PRSS1 (causing rare inherited hereditary pancreatitis), and LKB1/STK11 (explaining about 80% of Peutz–Jeghers cases) also increased the estimated risk of PDAC (17, 19, 20).