In addition, overexpressed enzymes like PHGDH and PSAT1 promote the MYC/miR-494/enhancer of zeste homolog 2 (EZH2) feed-forward loop and are at least partially driven by MYC/ATF4 signaling in Burkitt lymphoma cells to sustain metabolic reprogramming. This evidence concerns the gene EZH2 and Burkitt lymphoma.