Univariate Cox regression analysis yielded 20 PX-targeted genes associated with the survival in COAD patients (Figure 2(c)), and lasso regression analysis selected 14 genes as prognostic signatures (ITLN1, TPSG1, SLC4A4, PSCA, IGLV7-43, MMP10, C8G, EEF1A2, IGKV1D-12, PLIN1, RNU4-1, NDUFB1P1, CHGB, and CD177) (Figure 2(d)). This evidence concerns the gene RNU4-1 and colon adenocarcinoma.