Patients with high AGP levels had a lower freedom from worsening PAD status only in the mild disease subgroup (40% vs. 71%, p = 0.025), which likely represents the fact that this subgroup of patients are most likely to have significant absolute changes in ABI (e.g., patients with already low starting ABI’s are less likely to have a > 0.15 change over a 2-year period). This evidence concerns the gene ATP5MK and peripheral arterial disease.