The study of Li et al. revealed that USP10 was upregulated in colorectal cancer tissues compared to adjacent normal tissues and also could promote the proliferation and metastatic ability of colorectal cancer cells and the polarization of tumor-associated macrophages through interacting with and deubiquitinating NACHT, LRR, and PYD domain-containing protein 7 at its K379 lysine acceptor site which promoted downstream NF-κB signaling pathway nuclear translocation and activation of C-C motif chemokine ligand 2 transcription [29]. This evidence concerns the gene CCL2 and colorectal cancer.