Moreover, USP18 and USP33 expressions in IPMA and IPMC were higher than that in normal pancreatic tissues, while IPMN did not show significantly differential expression compared to normal pancreatic tissues (Figure 3(e)) and the USP39 expression was downregulated in IPMN compared to that in IPMA (Figure 3(e)). This evidence concerns the gene USP18 and pancreatic intraductal papillary-mucinous neoplasm.