Moreover, USP18 and USP33 expressions in IPMA and IPMC were higher than that in normal pancreatic tissues, while IPMN did not show significantly differential expression compared to normal pancreatic tissues (Figure 3(e)) and the USP39 expression was downregulated in IPMN compared to that in IPMA (Figure 3(e)). The gene discussed is USP33; the disease is pancreatic intraductal papillary-mucinous neoplasm.