IQR: interquartile range; SD: standard deviation; COPD: chronic obstructive pulmonary disease, SOFA: sequential organ failure assessment; APACHE-II: acute physiological and chronic health evaluation; CTSI: computed tomography severity index; MV: mechanical ventilation; HFNO: high flow nasal oxygenation; IL-6: interleukin 6; LDH: lactate dehydrogenase; NLR: neutrophil-to-lymphocyte ratio. This evidence concerns the gene IL6 and chronic obstructive pulmonary disease.