AQP4 and brain ischemia: However, the DAPC complex is disrupted by the destabilization of the astrocyte membrane after cerebral ischemia and the colocalization of AQP4 with α-DG, β-DG and agrin become weaker, thus suggesting that AQP4 depolarization might lead to the impairment of glymphatic function following the disruption of stability in the astrocyte endfeet membranes; however, these effects were rescued by pretreatment with XFZYD.