SETDB1 was reported to participate in regulating EMT in colorectal cancer (CRC) cells by binding to the P21 promoter and affecting its activity (Cao et al., 2020), in esophageal squamous cell carcinoma via interaction with SLC38A3 (Liu et al., 2020), and in HCC by interacting with Tiam1 (Zhang et al., 2018). The gene discussed is TIAM1; the disease is hepatocellular carcinoma.