Meanwhile, Hu et al. found that activating transcription factor 7-interacting protein (Atf7ip) and its binding partner SETDB1 were chromatin modifiers that mediated tumour immune escape, and deletion of either Atf7ip or SETDB1 stimulated antigen expression and presentation, promoted T-cell activation and infiltration, resulting in augmented antitumour immune responses. This evidence concerns the gene SETDB1 and neoplasm.