PDCD1 and Sepsis: For example, we recently showed in a cecal-ligation and puncture-induced murine polymicrobial sepsis model that LD01 treatment alleviated aspects of phagocyte immune dysfunction (Phares et al., 2021) corroborating the pathologic role of PD1 in altering microbial clearance and innate immunity in sepsis (Huang et al., 2009).